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Probiotics for Healthy Ageing: Lacticaseibacillus paracasei PS23™/PS23-HK™

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12 PUBLISHED SCIENTIFIC STUDIES

Home > Research > PS23 Clinical Studies

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Psychobiotic supplementation of HK-PS23 improves anxiety in highly stressed clinical nurses: a double-blind randomized placebo-controlled study

Blood cortisol levels significantly reduced in nurses taking PS23HK.

 

Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial

Plasma BCAAs (valine, leucine, and isoleucine) significantly increased and visceral adipose mass significantly reduced for elderly taking the OLEP formulation (omega-3 fatty acids, leucine, PS23). 

Clinical studies

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Preclinical studies

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Lactobacillus paracasei PS23 improves cognitive deficits via modulating the hippocampal gene expression and the gut microbiota in D-galactose-induced aging mice

Age-related cognitive decline ameliorated and motor and anxiety-related behavior improved after supplementation of PS23 and PS23HK in D-galactose-induced ageing mice models.  

 

Lacticaseibacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice

PS23 effectively modulates GI function and improves gut microbiota composition in SAMP8 ageing mice models. 

 

Coculture Strategy for Developing Lactobacillus paracasei PS23 Fermented Milk with Anti-Colitis Effect

PS23 fermented milk (PS23-FM) and PS23HK-FM are shown to have anti-colitis mechanisms in vitro.

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Lactobacillus paracasei PS23 dietary supplementation alleviates muscle aging via ghrelin stimulation in d-galactose-induced aging mice

PS23HK is shown to alleviate age-related muscle loss via ghrelin stimulation in vivo and in vitro.  

 

Lactobacillus paracasei PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice

PS23 extenuated sarcopenia progression during ageing through the preservation of mitochondrial function and increased antioxidant enzymes in SAMP8 ageing mice models. 

 

Lactobacillus paracasei PS23 reduced early-life stress abnormalities in maternal separation mouse model

Administration of PS23 and PS23HK showed positive behavioral effects and lowered stress hormone levels in maternal separation (MS) depressive mice models.  

 

Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms

Administration of PS23 and PS23HK reverses chronic depressive and anxiety behaviors in corticosterone-treated depressive mice models.  

 

Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Administration of PS23 delays the progression of age-related cognitive decline through prevention of oxidation and inflammation in SAMP8 ageing mice models.

Clinically shown to

  1. Reduce anxiety

  2. Relieve stress

Preclinical results

  1. Memory, cognition, and alertness boosted through stimulation of key brain molecules

  2. Muscle mass maintenance

Probiotic gut benefits

  1. Helps maintain a healthy gut for foundation of gut-brain axis

  2. Better GI function and more balanced microbiota composition

  3. Stronger gut barrier to reduce leaky gut

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